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The ADAURA trial reported its 5-year data at the plenary session of ASCO. No surprise, given the 3-year data was very compelling, adjuvant Osimertinib should be considered SOC for EGFR-mutated stage IB – IIIA NSCLC patients.

Neoadjuvant Pembro+chemo followed by surgery and adjuvant pembro had a superior PFS and pCR rate compared to neoadjuvant chemo followed by surgery. PCR rates were 30 vs. 11%, and PFS rates at 24 months were 62 vs. 41%, in the chemoIO vs. chemo alone groups, respectively. Still, OS was not significantly different, and this has yet to make it onto NCCN.

The NADIM-II study looked at perioperative Nivo+chemo vs. chemo alone in stIIIA – stIIIB NSCLC. High pCR rates with chemoIO are again seen, as in the Checkmate 816 and NADIM-I study, they were even higher in this cohort (37%), suggesting higher-stage patients derive the biggest benefit from neoadjuvant chemoIO. Pretty impressive results, however, I still must point out that this was a phase II study with a small sample size, OS benefits have not been demonstrated and this has yet to make it on to NCCN.