Article Search

A total of 287, 287, and 290 patients were assigned to the Tal-DP, (tal with dara and pomalidomide) Tal-D(Tal with dara) , and DPd (dara, pom and dex) groups, respectively. Progression-free survival (PFS) was 81.3% for TalDP and 77.6 % for Tal D compared to 51.2% for DPd. The overall response was higher with Tal-DP and Tal-D than with DPd (88.2% and 88.5% vs. 77.6%), as was complete response or better (71.1% and 69.0% vs. 34.5%) and measurable residual disease–negative complete response (52.3% and 46.3% vs. 15.9%) (P<0.001 for all comparisons). Overall survival at 24 months was 89.2% with Tal-DP, 87.9% with Tal-D, and 79.1% with DPd. Tal DP had less fatality secondary to adverse events (1.8%) vs Tal d 4% and DPd 4.6%. We will see more studies with cellular therapy combinations now and it seems promising, esp. with better control of toxicity.

Talquetamab plus daratumumab (with or without pomalidomide) delivered a striking progression-free survival (PFS) benefit over daratumumab plus pomalidomide and dexamethasone (DPd) in early-line relapsed/refractory myeloma, 24-month PFS of ~80% versus 51% and MRD-negative CR rates three times higher than the control arm. OS trending favorably but not yet mature. The GPRC5D toxicity profile is manageable but distinct, counsel patients upfront on taste changes, skin/nail effects, weight loss, and watch closely for ataxia/balance issues, which warrant holding the drug and early neurology involvement.

Quadruplet induction with isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa‑KRd) has reset expectations for transplant‑eligible NDMM and enables measurable residual disease (MRD)‑adapted strategies; MRD‑negativity at 10^-5 is strongly prognostic, and the necessity of autologous stem-cell transplantation (ASCT)—particularly tandem ASCT—amid deep responses is being re‑examined. Practically, MRD‑adapted consolidation after Isa‑KRd suggests no added depth from ASCT in MRD patients and no advantage for tandem ASCT over single ASCT + Isa‑KRd in MRD+ patients. So in day‑to‑day practice, this looks like a chance to de‑escalate transplant intensity while awaiting mature progression-free survival (PFS)/overall survival (OS) data.