Momelotinib for the treatment of myelofibrosis
Author(s): Prithviraj Bose
Source: https://doi.org/10.1182/blood.2023023719
Dr. Maen Hussein's Thoughts
This is a good review for a new option for MDS.
ABSTRACT
In September 2023, the US Food and Drug Administration approved momelotinib for the treatment of myelofibrosis (MF) with anemia, marking the fourth US regulatory approval of a Janus kinase inhibitor for MF. A positive opinion from the European Medicines Agency followed in November 2023. Momelotinib’s ability to address splenomegaly, symptoms, and anemia, including in patients with thrombocytopenia (with platelet counts of ≥25 × 109/L), the ease of switching from ruxolitinib, and good tolerability uniquely position it to substantially impact the MF treatment landscape.
