High-Dose Once-Daily Thoracic Radiotherapy in Limited-Stage Small-Cell Lung Cancer: CALGB 30610 (Alliance)/RTOG 0538
May 1, 2023
Twice-Daily radiation therapy is a long-standing SOC for LS-SCLC based upon improved OS in Intergroup0096, published nearly 25 years ago in 1999. This study compared 45 Gy at 1.5 Gy/fx BID vs. 45 Gy at 1.8 Gy/day. This regimen, however, has been slow to be adopted due to the inconvenience of BID therapy, as well as the modest radiation dose in control arm.
