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Overall Survival Among Patients With Hepatocellular Carcinoma Treated With External Beam Radiation Therapy: Individual Patient Data Outcomes From a Multinational Cohort

This was not randomized, so it did not establish equivalence between external beam radiation therapy (EBRT) and resection or ablation, but these are strong real-world data supporting EBRT as a frontline local option when standard curative approaches are not feasible. The early-stage, treatment-naïve outcomes make it hard to keep thinking of RT as just a salvage or bridge strategy in hepatocellular carcinoma (HCC), we likely underutilize this therapy.

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