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Monoclonal antibody targeting growth differentiation factor 15, a cytokine that causes cachexia in cancer. This one has promising results.

Growth differentiation factor 15 seems to be a driver in cancer cachexia. Ponsegromab targets this pathway and shows a meaningful improvement in weight, appetite and activity level in patients with a high level of this protein. It is fantastic to see a study like this and I’m excited to use this drug when available.