Prophylactic Radiation Therapy Versus Standard of Care for Patients With High-Risk Asymptomatic Bone Metastases: A Multicenter, Randomized Phase II Clinical Trial
From our radiation oncology colleagues, this is a study showing that for high-risk bone metastases, those treated prophylactically with radiation were associated with lower rates of skeletal related events. High risk was defined as a bulky (>2cm) lesion in the hip, long bone lesions occupying one-third (1/3) to two-thirds (2/3) of the cortical thickness, or disease of the vertebral body of the junctional spine or posterior element involvement.